Genetic basis of prostate cancer: Association studies

Abstract

Summary. Prostate cancer (PCa) is the most common malignancy in men. This paper reviews the results of previous work of the study group PROSTATSERBIA. In the candidate gene association study at the beginning of our research, we tested the association between several single nucleotide polymorphisms (SNPs) in the NOS3 gene and PCa risk and/or progression. In a population-based case-control study, we explored the possible association between PCa risk and seven SNPs identified by genome-wide association analyses (GWASs) in two chromosomal regions (8q24 and 17q12). For the first time in a European population, microRNA genetic variants and genetic variants in RNA-induced silencing complex (RISC) genes have been analyzed for their potential association with PCa.